The fine resolution has double the resolution, and does 2 samples/step and 3 loops, versus the less resolution of the general, 1 sample/step and 2 loops. The time for the fine is 2 hours, while the general is less than a half hour. So it comes down to do you need the finer resolution, and are you willing to pay the 4 times extra time to get that finer resolution. For me, in general I would use the general, but perhaps use the finer resolution when trying to find the frequency of substances over pathogens.
For more details, please check the link:
https://www.spooky2.com/forums/viewtopic.php?f=12&t=11566
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