Maybe also try anything related to the vagus nerve, PTSD, or neuroinflammation? My depression symptoms came from trauma and a brain infection I didn't know I had!
There are 4 peptide presets that mention anhedonia.
Depression
Depression is a prevalent mood disorder involving persistent low mood, anhedonia, cognitive deficits, and physiological changes such as reduced neuroplasticity, neuroinflammation, altered neurotransmitter balance, and disrupted circadian rhythms. The proposed polypeptides target evidence-based therapeutic axes from neuropeptide and bioregulatory research to modulate mood pathways, enhance resilience, and reduce inflammation.
Intense Sadness and Dejection
Intense sadness and dejection are core symptoms of major depressive disorder involving persistent low mood, anhedonia, emotional blunting, and impaired motivation often driven by HPA axis dysregulation, reduced neuroplasticity, oxidative stress, inflammation, and disrupted social bonding circuits.
Narcissistic Personality Disorder
Emotional Blunting and Detachment - Hemopressin - Acts as a selective CB1 receptor inverse agonist to normalize limbic anhedonia and facilitate deeper emotional processing.
Neurobiological Regulation of Suicidal Behavior
Antidepressant Modulation: MIF-1 - Acts as an endogenous modulator of the dopaminergic system and HPA axis to mitigate behavioral despair and anhedonia.
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