Experimental Molecular Frequencies for Capsaicin - USE AT OWN RISK -
Chemical Names: Capsaicin; 404-86-4; Zostrix; CAPSAICINE; Qutenza; Axsain
Molecular Formula: C18H27NO3
Molecular Weight: 305.418 g/mol
Capsaicin is a chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy - and radiotherapy-induced mucositis.
Capsaicin, a transient receptor potential vanilloid 1 receptor (TRPV1) agonist, activates TRPV1 ligand-gated cation channels on nociceptive nerve fibers, resulting in depolarization, initiation of action potential, and pain signal transmission to the spinal cord; capsaicin exposure results in subsequent desensitization of the sensory axons and inhibition of pain transmission initiation. In arthritis, capsaicin induces release of substance P, the principal chemomediator of pain impulses from the periphery to the CNS, from peripheral sensory neurons; after repeated application, capsaicin depletes the neuron of substance P and prevents reaccumulation. The functional link between substance P and the capsaicin receptor, TRPV1, is not well understood.
There are no known significant interactions.
The following adverse events occurred with topical patch administration.
>10%: Local: Localized erythema (63%), local pain (42%)
1% to 10%:
Cardiovascular: Hypertension (2%; transient)
Dermatologic: Papule (6%), local dryness (2%), pruritus (2%)
Gastrointestinal: Nausea (5%), vomiting (3%)
Local: Local pruritus (6%), localized edema (4%), local swelling (2%)
Respiratory: Nasopharyngitis (4%), sinusitis (3%), bronchitis (2%)
<1% (Limited to important or life-threatening): Abnormal skin odor, application site reactions (includes bruise, dermatitis, desquamation, excoriation, hyperesthesia, inflammation, paresthesia, urticaria), burning sensation of skin, cough, dizziness, dysgeusia, headache, hypoesthesia, peripheral edema, peripheral sensory neuropathy, throat irritation
Concerns related to adverse effects:
• Burns: May cause serious burns (eg, first- to third-degree chemical burns) at the application site. In some cases, hospitalization has been required. Discontinue use and seek medical attention if signs of skin injury (eg, pain, swelling, or blistering) occur following application (FDA Drug Safety Communication, 2012).
• CNS depression: May cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery or driving).
• Cardiovascular disease: Use with caution in patients with uncontrolled hypertension or a history of cardiovascular events; transient increases in blood pressure due to treatment-related pain have occurred during and after application of RX patch.
• Cerebrovascular disease: Use with caution in patients with a history of cerebrovascular events; transient increases in blood pressure due to treatment-related pain have occurred during and after application of RX patch.
A study published in Cancer Research found that capsaicin caused cancer cells to commit suicide. The substance caused almost 80 percent of prostate cancer cells to die in mice, and prostate tumors treated with capsaicin were about one-fifth the size of those in untreated mice.
Remote frequencies for Capsaicin sub-harmonics 65-87
MW Capsaicin Remote.txt
Contact frequencies for Capsaicin sub-harmonics 64-87
MW Capsaicin Contact.txt
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