MW Beta-Boswellic acid aka Indian Frankencensce

Experimental Molecular Frequencies for beta-Boswellic acid - USE AT OWN RISK -

Chemical Names: Beta-Boswellic acid; Boswellic acid; No translation; 631-69-6; CHEMBL267225; (3|A)-3-hydroxyurs-12-en-24-oic acid
Molecular Formula: C30H48O3
Molecular Weight: 456.711 g/mol
Common Name(s): Indian frankincense tree , “ salai guggal ” (term for the gum resin of the tree)

The gum resin of Boswellia serrata contains the biologically active boswellic acid (3-alpha-hydroxy-urs-12-en-23-oic acid) and its derivatives. 3

Boswellin (patented product of Sabinsa Corporation ) 2 is the standardized ethanol extract of Boswellia serrata gum resin. It contains 60% to 65% boswellic acids and can be found in health food stores. 2

Isolation and identification of a 4-O-methyl-glucuronoarabinogalactan from Boswellia serrata have been performed. 4

Other compounds found in the gum resin include volatile oils, terpinols, arabinose, xylose, galactose, uronic acids, beta-sitosterin and phlobaphenes. 5

Uses and Pharmacology

Boswellic acids in vitro are specific inhibitors of 5-lipoxygenase, the key enzyme of leukotriene biosynthesis. Leukotrienes are biochemicals in the body that maintain inflammation. Boswellic acids may offer an alternative to corticosteroid and NSAID therapy in treating such inflammatory conditions as arthritis, tendinitis, or bursitis. 2 , 3
Animal data

Anti-inflammatory activity has been studied in animals. 3 The plant extract displays marked anti-inflammatory action as well as anti-arthritic activity with no significant side effects in rats. 6 One report evaluates boswellic acid inhibition on leukotriene synthesis (via 5-lipoxygenase), finding it to have no effect on 12-lipoxygenase, cyclooxygenase, or the peroxidation of arachidonic acid by iron and ascorbate, suggesting the boswellic acid component to be a specific, non-redox inhibitor of leukotriene synthesis. 7 Similar results were found in rat peritoneal neutrophils. 8 , 9
Clinical data

A mixture of boswellic acid and its derivatives is used in India to treat arthritis. 3 Boswellia serrata in an herbomineral combination was studied in 42 osteoarthritic patients in a randomized, double blind, placebo controlled crossover study. Pain and disability scores were decreased significantly, but radiological assessment showed no change. 10

Ulcerative colitis, also an inflammatory disease, seems to benefit from Boswellia's ability to inhibit 5-lipoxygenase as well. In patients given Boswellia serrata gum resin preparation (350 mg 3 times daily) for 6 weeks compared with sulfasalazine (1 g 3 times daily), parameters of ulcerative colitis (eg, stool properties, histopathology, rectal biopsies, blood work) were improved. Remission was 82% with the resin and 75% with sulfasalazine. 11
Other uses

In an immunological study, boswellic acids also have been shown to possess anticomplementary activity via C3-convertase inhibition. 12 C3-convertase is involved in the production of anaphylatoxin. 13

Salai guggal, the gum resin exudate of Boswellia serrata , has been evaluated for effects on: Glycosaminoglycan metabolism in rats, 14 humoral immune response, inhibiting infiltration of polymorphonuclear leukocytes in rats, 15 and some analgesic and psychopharmacological effects. 16

An extract of frankincense (H15) was studied in arthritis at a dose of 3.6 gm daily. The gum resin of frankincense has been used at a daily dose of 900 mg for bronchial asthma. 17 , 18

Information regarding safety and efficacy in pregnancy and lactation is lacking.

None well documented.
Adverse Reactions

The limited data available on toxicity of the Indian frankincense tree include: No side effects, 2 , 5 no cytotoxic effect, 15 no effects on cardiovascular, respiratory or CNS function, no ulcerogenic effects, 6 or “side effects observed...did not necessitate withdrawal of treatment.” 10

Research reveals little or no information regarding toxicology with the use of this product.

Remote frequencies for beta-Boswellic acid sub-harmonics 66-87

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Contact frequencies for beta-Boswellic acid sub-harmonics 64-87

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