Yes. You can simply click on "Restore Generator Defaults" menu command in the File menu to get the default settings. This will not affect running programs on your generators. You can also click on any preset or shell preset, and this will not affect any running generators. You can even test your new settings on the VG (Virtual Generator) in the Control tab to make sure your program / preset behaves as you wish, without affecting any running generator.
You can even save presets, or create chained presets and save them too, without affecting any running generators.
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